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产品详情
操作说明
注意事项
Product Information
|
Description |
CITED2 rabbit polyclonal antibody |
|
Protein full name |
Cbp/p300-interacting transactivator 2 |
|
Synonyms |
MSG-related protein 1, MRG-1, P35srj, Mrg1, Cited2, Msg2 |
|
Immunogen |
Recombinant protein corresponding to Mouse CITED2 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
28 kDa |
|
Observed MW. |
28 kDa |
|
Uniprot ID |
O35740, Q99MA1 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
brain, heart |
Background
CITED2, also named as P35srj, is a cAMP-responsive element-binding protein (CBP)/p300-transactivator, with an ED(Glu/Asp)-rich C-terminal domain that acts as an important modulator in the development of the heart .It is proposed to be a negative regulator of HIF-1α through its competitive binding to the CH1 domain of CBP/p300, which mediated signaling and to a decrease in HIF-1-responsive genes such as VEGF. In addition, it is also a co-activator of the transcriptional activity of the TFAP2 isoform, which is an extensively expressed nuclear protein with functions in embryogenesis, inflammation, and stress responses.
Images
|
|
Western blot analysis of CITED2 (GB111129) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室