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Anti -Rb2 p130 Rabbit pAb
价格：
在线咨询
货号：
KT011843
产品规格：
100 μL
Applications：
IHC/IF
Species：
M,R
购买数量：
产品详情
操作说明
注意事项
Product Information
|
Description |
Rb2 p130 rabbit polyclonal antibody |
|
Protein full name |
Retinoblastoma-like protein 2 |
|
Synonyms |
130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, Rbl2 |
|
Immunogen |
Recombinant protein corresponding to Mouse Rb2 p130 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus |
|
Uniprot ID |
Q64700, O55081 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
IHC/IF |
Mouse, Rat |
1: 500-1: 1500 |
brain, testis |
Background
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
Images
|
|
Immunofluorescence of paraffin embedded mouse brain using kb12 (GB111770) at dilution of 1:700 (300x lens) |
|
|
Immunofluorescence of paraffin embedded rat testis using kb12 (GB111770) at dilution of 1:700 (260x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室