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Anti -Securin Rabbit pAb
价格：
在线咨询
货号：
KT011701
产品规格：
Applications：
WB | IHC | IF
Species：
M,R | H,M,R
购买数量：
产品详情
操作说明
注意事项
Product Information
|
Description |
Securin rabbit polyclonal antibody |
|
Protein full name |
Securin |
|
Synonyms |
Pituitary tumor-transforming gene 1 protein, Pttg1, Pttg, Cut2, EAP1, ESP1, TUTR1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Securin |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus, Cytoplasm |
|
Predicted MW. |
22 kDa |
|
Observed MW. |
26 kDa |
|
Uniprot ID |
O95997, Q9CQJ7, P97613 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
testis, cecum, skin, epityphlon |
|
IHC/IF |
Human, Mouse, Rat |
1: 500-1: 2800 |
placenta, testis |
Background
PTTG1 is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The protein has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. This protein contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.
Images
|
|
Western blot analysis of Securin (GB111047) at dilution of 1: 500 |
|
|
Immunohistochemistry of paraffin embedded mouse placenta using Securin (GB111047) at dilution of 1: 1400 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat testis using Securin (GB111047) at dilution of 1: 1400 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室