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Product Information
Description |
Cyclin A2 rabbit polyclonal |
Protein full name |
Cyclin-A2 |
Synonyms |
Cyclin-A, Cyclin A, CCNA2, CCN1, CCNA |
Immunogen |
Recombinant protein corresponding to Human Cyclin A2 |
Isotype |
IgG |
Purity |
Affinity purification |
Subcellular location |
|
Predicted MW. |
49 kDa |
Observed MW. |
55 kDa |
Uniprot ID |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
WB |
Human, Mouse |
1: 500-1: 1000 |
lymph nodes, spleen |
IHC |
Human, Mouse, Rat |
1: 600-1: 1200 |
lymph nodes, brain, testis |
IF |
Human, Mouse, Rat |
1: 250-1: 1000 |
lung cancer, kidney |
Background
Cyclin A2 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. Cyclin A2 binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Cyclin A2 could be phosphorylated during the G2/M.
Images
Western blot analysis of Cyclin A2 (GB111132) at dilution of 1: 1000 Lane 1: HCT116 cell lysate Lane 2: Jurkat cell lysate Lane 3: HT29 cell lysate Lane 4: K562 cell lysate Lane 5: SW480 cell lysate Lane 6: Mouse lymph nodes tissue lysate Lane 7: Mouse spleen tissue lysate |
|
Immunohistochemistry analysis of paraffin-embedded using human lymph nodes Cyclin A2 (GB111132) at dilution of 1: 1000 |
|
Immunohistochemistry analysis of paraffin-embedded using mouse brain Cyclin A2 (GB111132) at dilution of 1: 600 |
|
Immunohistochemistry analysis of paraffin-embedded using rat testis Cyclin A2 (GB111132) at dilution of 1: 600 |
|
Immunofluorescent analysis of paraffin-embedded using human lung cancer Cyclin A2 (GB111132) at dilution of 1: 500 |
|
Immunofluorescent analysis of paraffin-embedded using mouse kidney Cyclin A2 (GB111132) at dilution of 1: 500 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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