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产品详情
操作说明
注意事项
Product Information
|
Description |
p21 rabbit polyclonal |
|
Protein full name |
Cyclin-dependent kinase inhibitor 1 |
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Synonyms |
CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, p21 cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse p21 |
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Isotype |
IgG |
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Purity |
Affinity purification |
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Subcellular location |
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Uniprot ID |
Applications
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Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human, Mouse, Rat |
1: 200-1: 800 |
kidney, brain, heart, inflammatory lung |
|
IF |
Human, Mouse, Rat |
1: 200-1: 800 |
kidney, brain, heart, inflammatory lung |
Background
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding.
Images
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Immunohistochemistry analysis of paraffin-embedded mice heLa tumor using p21 (GB11153) at dilution of 1: 800.
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Immunohistochemistry analysis of paraffin-embedded rat kidney in using p21 (GB11153) at dilution of 1: 400
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Immunohistochemistry analysis of paraffin-embedded tumour by rat brain using p21 (GB11153) at dilution of 1: 400
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Immunohistochemistry analysis of paraffin-embedded mouse kidney in using P21(GB11153) at dilution of 1:200
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Immunohistochemistry analysis of paraffin-embedded mouse inflammatory lung in using P21(GB11153) at dilution of 1:400
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Immunohistochemistry analysis of paraffin-embedded mouse heart in using P21(GB11153) at dilution of 1:400
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Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室