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产品详情
操作说明
注意事项
Product Information
|
Description |
Bub3 rabbit polyclonal antibody |
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Protein full name |
Mitotic checkpoint protein BUB3 |
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Synonyms |
WD repeat type I transmembrane protein A72.5, Bub3 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Bub3 |
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Isotype |
IgG |
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Purity |
Affinity purification |
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Subcellular location |
Nucleus |
|
Uniprot ID |
O43684, Q9WVA3 |
Applications
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Applications |
Species |
Dilution |
Positive Sample |
|
IHC/IF |
Human, Mouse, Rat |
1: 500-1: 3000 |
brain, breast cancer, lung, lung cancer, pancreas, small intestine, thyroid gland |
Background
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20.
Images
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Immunohistochemistry of paraffin embedded human breast cancer using BuB3 (GB111183) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded human lung cancer using BuB3 (GB111183) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded human thyroid gland using BuB3 (GB111183) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse lung using BuB3 (GB111183) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse pancreas using BuB3 (GB111183) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using BuB3 (GB111183) at dilution of 1:1400 (400x lens) |
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Immunohistochemistry of paraffin embedded rat lung using BuB3 (GB111183) at dilution of 1:1400 (400x lens) |
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Immunofluorescence of paraffin embedded human breast cancer using BuB3 (GB111183) at dilution of 1:1300 (400x lens) |
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Immunofluorescence of paraffin embedded mouse brain using BuB3 (GB111183) at dilution of 1:1300 (400x lens) |
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Immunofluorescence of paraffin embedded rat pancreas using BuB3 (GB111183) at dilution of 1:1300 (400x lens) |
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Immunofluorescence of paraffin embedded rat small intestine using BuB3 (GB111183) at dilution of 1:1300 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室