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产品详情
操作说明
注意事项
Product Information
|
Description |
c-kit rabbit polyclonal |
|
Protein full name |
Mast/stem cell growth factor receptor Kit |
|
Synonyms |
C Kit, CD117, c-Kit, KIT, PBT, Proto-oncogene c-Kit, SCFR, Tyrosine protein kinase Kit, Sl |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse c-kit |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Predicted MW. |
109 kDa |
|
Observed MW. |
120-140 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Mouse, Rat |
1: 400-1: 800 |
brain, hippocampus |
|
IHC/IF |
Mouse, Rat |
1: 500-1: 1000 |
brain, testis |
Background
KIT, also named as SCFR, c-Kit and CD117, is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. It is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand(SCF) binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Phosphorylation at tyrosine 721 of KIT allows binding and activation of PI3 kinase.
Images
|
|
Western blot analysis of c-kit (GB113799) at dilution of 1: 800 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse brain using c-kit (GB113799) at dilution of 1: 1000 |
|
|
Immunohistochemistry analysis of paraffin-embedded rat brain using c-kit (GB113799) at dilution of 1: 1000 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse testis using c-kit (GB113799) at dilution of 1: 1000 |
|
|
Immunohistochemistry analysis of paraffin-embedded rat testis using c-kit (GB113799) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室