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产品详情
操作说明
注意事项
Product Information
|
Description |
CD11b rabbit polyclonal |
|
Protein full name |
Integrin alpha-M |
|
Synonyms |
ITGAM, CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6, integrin subunit alpha M |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse CD11b |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
applications |
species |
dilution |
Positive tissue |
|
IHC |
Mouse, Rat |
1: 500-1: 1000 |
septic lung, spleen |
|
IF |
Mouse, Rat |
1: 500-1: 1000 |
septic lung |
Background
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Images
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|
Immunohistochemistry analysis of paraffin-embedded mouse septic lung using CD11b(GB11058) at dilution of 1: 500 |
|
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Immunohistochemistry analysis of paraffin-embedded rat septic lung using CD11b(GB11058) at dilution of 1: 500 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse spleen using CD11b(GB11058) at dilution of 1: 500 |
|
|
Immunofluorescent analysis of paraformaldehyde-fixed mouse septic lung using CD11b(GB11058) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
Publications:
|
|
Title |
Journal |
Pubmed ID |
Application |
|
1 |
Necroptosis is active and contributes to intestinal injury in a piglet model with lipopolysaccharide challenge. |
Cell Death & Disease |
33431831 |
IHC |
|
2 |
Loss of natural resistance to schistosome in T cell deficient rat. |
PLoS Neglected Tropical Diseases |
33347431 |
IHC |
|
3 |
Long-term inhibition of dipeptidyl-peptidase 4 reduces islet infiltration and downregulates IL-1β and IL-12 in NOD mice. |
International Immunopharmacology |
33182020 |
IHC |
|
4 |
Involvement of kindlin-2 in irisin's protection against ischaemia reperfusion-induced liver injury in high-fat diet-fed mice. |
Journal of Cellular and Molecular Medicine |
32954626 |
IHC，IF |
|
5 |
Optimization Strategy for Generating Gene-edited Tibet Minipigs by Synchronized Oestrus and Cytoplasmic Microinjection. |
International Journal of Biological Sciences |
31754342 |
IHC |
|
6 |
MMI-0100 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice through Targeting MK2 Pathway. |
Molecules (Basel, Switzerland) |
31382637 |
IF |
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室