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产品详情
操作说明
注意事项
Product Information
|
Description |
BNIP3 rabbit polyclonal antibody |
|
Protein full name |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 |
|
Synonyms |
Bnip3, Nip3 |
|
Immunogen |
Recombinant protein corresponding to Mouse BNIP3 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm |
|
Uniprot ID |
Q12983, O55003 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
IHC/IF |
Human, Mouse |
1: 1000-1: 2000 |
breast cancer, colon cancer, spleen, testis |
Background
The BNIP3 is an apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
Images
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Immunohistochemistry of paraffin embedded human breast cancer using BNIP3 (GB111204) at dilution of 1:1000 (400x lens) |
|
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Immunohistochemistry of paraffin embedded human colon cancer using BNIP3 (GB111204) at dilution of 1:1000 (400x lens) |
|
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Immunohistochemistry of paraffin embedded mouse spleen using BNIP3 (GB111204) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse testis using BNIP3 (GB111204) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室