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产品详情
操作说明
注意事项
Product Information
|
Description |
TDP1 rabbit polyclonal antibody |
|
Protein full name |
Tyrosyl-DNA phosphodiesterase 1 |
|
Synonyms |
Tyr-DNA phosphodiesterase 1, Protein expressed in male leptotene and zygotene spermatocytes 501, MLZ-501, Tdp1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse TDP1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
69 kDa |
|
Observed MW. |
69 kDa |
|
Uniprot ID |
Q8BJ37, Q4G056 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
stomach, liver, kidney |
Background
The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1).
Images
|
|
Western blot analysis of TDP1 (GB111302) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室