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Anti -Cytokeratin 1 Rabbit pAb
价格：
在线咨询
货号：
KT011902
产品规格：
100ul
Applications：
WB
Species：
H/M/R
购买数量：
产品详情
操作说明
注意事项
Product Information
|
Description |
Cytokeratin 1 rabbit polyclonal antibody |
|
Protein full name |
Keratin, type II cytoskeletal 1 |
|
Synonyms |
67 kDa cytokeratin, Cytokeratin-1, Keratin-1, CK-1, K1, Type-II keratin Kb1, Krt1, Krt2-1, EHK1, Keratin type II cytoskeletal 1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Cytokeratin 1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
66 kDa |
|
Observed MW. |
66 kDa |
|
Uniprot ID |
P04264, P04104, Q6IMF3 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
skin |
Background
Cytokeratin 1 is a heterotetramer of two type I as well as two type II keratins localized in the cell membrane and is generally associated with keratin-10 . It has been suggested to regulate the activity of kinases such as PKC/SRC via binding to integrin beta-1 and the receptor of activated protein kinase C. Cytokeratin 1 and its heterodimer partner KRT10 are the major constituents of 4 intermediate filament cytoskeleton in suprabasal epidermis/keratinocytes, and their upregulation precedes expression of filaggrin and cornified envelope proteins. Covalent crosslinking of cytokeratin 1 but not of KRT10 to these proteins, in addition to a complex series of lipids, ultimately forms the cornified/lipid envelope, that constitutes the epidermal barrier together with Langerhans cells.
Images
|
Western blot analysis of cytokeratin-1 (GB111017) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室