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产品详情
操作说明
注意事项
Product Information
|
Description |
C2 rabbit polyclonal |
|
Protein full name |
Complement C2 |
|
Synonyms |
C2, ARMD14, CO2, Complement component 2, Complement C2 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Complement C2 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
85 kDa |
|
Observed MW. |
102 kDa |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
liver, lung, stomach |
Background
Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical pathway of the complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases. In the classical and lectin pathways of complement activation, formation of the C3-convertase and C5-convertases requires binding of C2 to an activated surface-bound C4b in the presence of Mg2+; the resultant C4bC2 complex is then cleaved by C1s or MASP2 into C2a and C2b. It is thought that cleavage of C2 by C1s, while bound to C4b, results in a conformational rotation of C2b whereas the released C2a fragment may retain most of its original structure.
Images
|
Western blot analysis of Complement C2 (GB11617) at dilution of 1: 1000 Lane 1: HeLa cell lysate Lane 2: HepG2 cell lysate Lane 3: A431 cell lysate Lane 4: Mouse liver tissue lysate Lane 5: Mouse lung tissue lysate Lane 6: Rat liver tissue lysate Lane 7: Rat stomach tissue lysate
|
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室