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产品详情
操作说明
注意事项
Product Information
|
Description |
BLNK rabbit polyclonal |
|
Protein full name |
B-cell linker protein |
|
Synonyms |
Blnk, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, Bca, B-cell linker |
|
Immunogen |
Recombinant protein corresponding to Mouse BLNK |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Membrane |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse, Rat |
1: 3000-1: 5000 |
spleen |
|
IF |
Mouse, Rat |
1: 1500-1: 2500 |
spleen |
Background
The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.
Images
|
Immunohistochemistry analysis of paraffin-embedded mouse spleen using BLNK (GB11734) at dilution of 1: 3000
|
|
Immunohistochemistry analysis of paraffin-embedded mouse spleen using BLNK (GB11734) at dilution of 1: 3000
|
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室