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产品详情
操作说明
注意事项
Product Information
|
Description |
NOTCH3 rabbit polyclonal antibody |
|
Protein full name |
Neurogenic locus notch homolog protein 3 |
|
Synonyms |
Notch 3, NOTCH3, Notch 3 extracellular truncation, Notch 3 intracellular domain, CADASIL, CASIL |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse NOTCH3 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
244 kDa |
|
Observed MW. |
110 kDa (cleaved) |
|
Uniprot ID |
Q9UM47 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Human |
1: 100-1: 500 |
HeLa, MCF-7, K562 |
Background
NOTCH3 belongs to the NOTCH family. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH3 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Images
|
|
Western blot analysis of Notch3 at dilution of 1: 100 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室