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产品详情
操作说明
注意事项
Product Information
|
Description |
MAML1 rabbit polyclonal antibody |
|
Protein full name |
Mastermind-like protein 1 |
|
Synonyms |
Mam-1, Maml1, Kiaa0200, Mastermind like 1 |
|
Immunogen |
Recombinant protein corresponding to Mouse MAML1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
108 kDa |
|
Observed MW. |
130 kDa |
|
Uniprot ID |
Q92585, Q6T264 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse |
1: 500-1: 1000 |
lung, thymus |
Background
MAML1, also named as KIAA0200 and Mam-1 , belongs to the mastermind family. It acts as a transcriptional coactivator for NOTCH proteins. MAML1 has been shown to amplify NOTCH-induced transcription of HES1. It enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. MAML1 binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. It plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. The calculated molecular weight of MAML1 is 108 kDa, but modified MAML1 is about 120-130 kDa.
Images
|
|
Western blot analysis of maml1 at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室