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产品详情
操作说明
注意事项
Product Information
|
Description |
IKB alpha rabbit polyclonal |
|
Protein full name |
NF-kappa-B inhibitor alpha |
|
Synonyms |
NFKBIA, IKBA, MAD-3, NFKBI, NFKB inhibitor alpha |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse IKBα |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm, Nucleus |
|
Uniprot ID |
P25963, Q9Z1E3 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human |
1: 500-1: 3000 |
lung cancer, liver cancer, stomach cancer |
|
IF |
Human |
1: 500-1: 1000 |
lung cancer, liver cancer, stomach cancer |
Background
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Images
|
Immunohistochemistry analysis of paraffin-embedded human lung cancer using IKBα (GB11212) at dilution of 1: 1000 |
|
|
Immunohistochemistry analysis of paraffin-embedded human colon cancer using IKBα (GB11212) at dilution of 1: 1000
|
|
|
Immunohistochemistry analysis of paraffin-embedded human stomach cancer using IKBα (GB11212) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室