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产品详情
操作说明
注意事项
Product Information
|
Description |
Frizzled 6 rabbit polyclonal antibody |
|
Protein full name |
Frizzled-6 |
|
Synonyms |
Fz-6, mFz6, Fzd6, NDNC10, Frizzled homolog 6, Frizzled family receptor 6, Frizzled 6 seven transmembrane spanning receptor, hFz6 |
|
Immunogen |
Recombinant protein corresponding to Mouse Frizzled 6 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
79 kDa |
|
Observed MW. |
72 kDa |
|
Uniprot ID |
Q61089 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Mouse, Rat |
1: 1000-1: 2000 |
liver, kidney, prostate, pancreas |
Background
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis.
Images
|
Western blot analysis of Frizzled-6 (GB112220) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室