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产品详情
操作说明
注意事项
Product Information
|
Description |
Beclin 1 rabbit polyclonal antibody |
|
Protein full name |
Beclin-1 |
|
Synonyms |
Coiled-coil myosin-like BCL2-interacting protein, Protein GT197, BECN1, GT197, APG6, VPS30, Protein GT197 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Human Beclin 1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
52 kDa |
|
Observed MW. |
60 kDa |
|
Uniprot ID |
Q14457, O88597, Q91XJ1 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
brain, spleen, kidney |
Background
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.
Images
|
|
Western blot analysis of Beclin1 (GB112053) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室