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Anti - SIRT1 Rabbit pAb
价格：
在线咨询
货号：
KT012158
产品规格：
100 μL
Applications：
IHC/IF
Species：
H,M,R
购买数量：
产品详情
操作说明
注意事项
Product Information
|
Description |
SIRT1 rabbit polyclonal antibody |
|
Protein full name |
NAD-dependent protein deacetylase sirtuin-1 |
|
Synonyms |
SIR2L1,SIR2,hSIR2,SIR2alpha,Sirtuin 1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse SIRT1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus, Cytoplasm |
|
Uniprot ID |
Q923E4, Q96EB6 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
IHC/IF |
Human, Mouse, Rat |
1: 500-1: 2000 |
testis, tonsil |
Background
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD+/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction.
Images
|
|
Immunohistochemistry of paraffin embedded human tonsil using SIRT1 (GB11171) at dilution of 1:1000 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded mouse testis using SIRT1 (GB11171) at dilution of 1:1000 (200x lens)
|
|
Immunohistochemistry of paraffin embedded rat testis using SIRT1 (GB11171) at dilution of 1:1000 (200x lens)
|
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室