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产品详情
操作说明
注意事项
Product Information
|
Description |
SIK1 rabbit polyclonal antibody |
|
Protein full name |
Serine/threonine-protein kinase SIK1 |
|
Synonyms |
HRT-20, Myocardial SNF1-like kinase, Serine/threonine-protein kinase SNF1-like kinase 1, Salt-inducible kinase 1, SIK1 |
|
Immunogen |
Recombinant protein corresponding to Mouse SIK1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
85 kDa |
|
Observed MW. |
90 kDa |
|
Uniprot ID |
Q60670, Q9R1U5 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
stomach, lung, ovary, heart |
Background
SIK1(Salt-inducible kinase 1) is also named as SIK, SNF1LK and belongs to the CAMK Ser/Thr protein kinase family. It associates constitutively with the NK regulatory complex and is responsible for increases in its catalytic activity following small elevations in intracellular sodium concentrations. SIK1 is required for phosphorylation of class II HDACs and for expression of MEF2 target genes in myocytes. Defects in SIK1 may be associated with some cancers, such as breast cancers. Loss of SIK1 correlates with poor patient outcome in breast cancers.
Images
|
|
Western blot analysis of Msk (GB111034) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室