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产品详情
操作说明
注意事项
Product Information
|
Description |
BRCA2 rabbit polyclonal antibody |
|
Protein full name |
Breast cancer type 2 susceptibility protein |
|
Synonyms |
Brca2, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, Breast cancer 2, DNA repair associated, breast cancer 2, Early onset, BRCA2 DNA repair associated |
|
Immunogen |
Recombinant protein corresponding to Mouse BRCA2 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm, Nucleus |
|
Uniprot ID |
P97929, O35923 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
IHC/IF |
Mouse, Rat |
1:1500-1:3000 |
brain, hippocampus |
Background
BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation.
Images
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|
Immunohistochemistry of paraffin embedded mouse hippocampus using BRCA2 (GB111138) at dilution of 1:2200 (400x lens) |
|
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Immunohistochemistry of paraffin embedded rat hippocampus using BRCA2 (GB111138) at dilution of 1:1100 (400x lens) |
|
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Immunofluorescence of paraffin embedded mouse brain using BRCA2 (GB111138) at dilution of 1:2200 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using BRCA2 (GB111138) at dilution of 1:2200 (400x lens) |
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Immunofluorescence of paraffin embedded rat hippocampus using BRCA2 (GB111138) at dilution of 1:2200 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
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地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室