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产品详情
操作说明
注意事项
Product Information
|
Description |
Clusterin rabbit polyclonal antibody |
|
Protein full name |
Clusterin |
|
Synonyms |
Apolipoprotein J, Apo-J, Clustrin, Sulfated glycoprotein 2, SGP-2, Apoj, Clu |
|
Immunogen |
Recombinant protein corresponding to Mouse Clusterin |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm, Nucleus, Secreted |
|
Uniprot ID |
Q06890, P05371 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse, Rat |
1: 500-1: 1500 |
lung, ovary, pancreas |
Background
The Clusterin functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins (By similarity).When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Modulates NF-kappa-B transcriptional activity. Following stress, promotes apoptosis . Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation. Following ER stress, suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5. When secreted, does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity.
Images
|
|
Immunohistochemistry of paraffin embedded mouse lung using clusterin (GB111144) at dilution of 1:900 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded mouse ovary using clusterin (GB111144) at dilution of 1:900 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded mouse pancreas using clusterin (GB111144) at dilution of 1:900 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat lung using clusterin (GB111144) at dilution of 1:900 (400x lens) |
|
|
Immunohistochemistry of paraffin embedded rat pancreas using clusterin (GB111144) at dilution of 1:900 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室