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产品详情
操作说明
注意事项
Product Information
|
Description |
RNF8 rabbit polyclonal antibody |
|
Protein full name |
E3 ubiquitin-protein ligase RNF8 |
|
Synonyms |
ActA-interacting protein 37, AIP37, LaXp180, RING finger protein 8, Rnf8, RING-type E3 ubiquitin transferase RNF8 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse RNF8 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
56 kDa |
|
Observed MW. |
56 kDa |
|
Uniprot ID |
Q8VC56, Q4KLN8 |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1: 500-1: 1000 |
brain |
Background
The RNF8 (also named as KIAA0646 or E3 ubiquitin-protein ligase RNF8) contains one RING-type zinc finger and one FHA domain. RNF8 localizes in the nucleus and belongs to the RNF8 family. E2-E3 ubiquitin ligase complex is composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites.
Images
|
|
Western blot analysis of RNF8 (GB111158) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室