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产品详情
操作说明
注意事项
Product Information
|
Description |
SHP2 rabbit polyclonal |
|
Protein full name |
Tyrosine-protein phosphatase non-receptor type 11 |
|
Synonyms |
SHP2, PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, Protein tyrosine phosphatase, non-receptor type 11 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse SHP2 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Rat |
1: 1000-1: 2000 |
lung, colon |
|
IF |
Rat |
1: 500-1: 1000 |
lung, colon |
Background
PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
Images
|
Immunohistochemistry analysis of paraffin-embedded rat lung using SHP2 (GB11698) at dilution of 1: 1000
|
|
Immunohistochemistry analysis of paraffin-embedded rat colon using SHP2 (GB11698) at dilution of 1: 1000
|
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室