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Anti -GBA Rabbit pAb
价格：
在线咨询
货号：
KT011511
产品规格：
100 μL
Applications：
IHC、IF
Species：
M,R | M,R
购买数量：
产品详情
操作说明
注意事项
Product Information
|
Description |
GBA rabbit polyclonal |
|
Protein full name |
Lysosomal acid glucosylceramidase |
|
Synonyms |
GBA, GBA1, GCB, GLUC, Glucosylceramidase beta, Glucocerebrosidase, BETA GLUCOSIDASE, ACID, Gba protein |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse GBA |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cytoplasm |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse, Rat |
1: 1000-1: 2000 |
kidney, stomach, small intestine, fetal rat |
|
IF |
Mouse, Rat |
1: 500-1: 1000 |
kidney, stomach, small intestine, fetal rat |
Background
The GBA is a glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes . Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism . May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol . The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol .
Images
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|
Immunohistochemistry analysis of paraffin-embedded mouse kidney using GBA (GB111110) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded rat kidney using GBA (GB111110) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse stomach using GBA (GB111110) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded rat small intestine using GBA (GB111110) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded mouse fetal rat using GBA (GB111110) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室