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产品详情
操作说明
注意事项
Product Information
|
Description |
SAMHD1 rabbit polyclonal |
|
Protein full name |
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 |
|
Synonyms |
dNTPase, Interferon-gamma-inducible protein Mg11, SAMHD1, Mg21, SAM domain and HD domain-containing protein 1, mSAMHD1 |
|
Immunogen |
Recombinant protein corresponding to Mouse SAMHD1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
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Predicted MW. |
76 kDa |
|
Observed MW. |
72 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
brain |
|
IHC |
Human, Mouse, Rat |
1: 1000-1: 4000 |
lung cancer, lung, liver cancer, liver, esophageal cancer, colon cancer, brain, spinal cord, heart, ovary |
|
IF |
Human, Mouse, Rat |
1: 1000-1: 2000 |
kidney cancer, lung, small intestine, spleen, placenta |
Background
The SAMHD1 is a putative nuclease involved in innate immune response by acting as a negative regulator of the cell-intrinsic antiviral response. It is a host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling.
Images
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Western blot analysis of SAMHD1 (GB111331) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat lung using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human liver cancer using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse liver using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded human colon cancer using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat brain using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse spinal cord using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse heart using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded rat ovary using SAMHD1 (GB111331) at dilution of 1: 2000 |
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Immunofluorescent analysis of paraformaldehyde-fixed human kidney cancer using SAMHD1 (GB111331) at dilution of 1: 1100 |
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Immunofluorescent analysis of paraformaldehyde-fixed mouse lung using SAMHD1 (GB111331) at dilution of 1: 1100 |
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Immunofluorescent analysis of paraformaldehyde-fixed mouse small intestine using SAMHD1 (GB111331) at dilution of 1: 1100 |
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Immunofluorescent analysis of paraformaldehyde-fixed rat spleen using SAMHD1 (GB111331) at dilution of 1: 1100 |
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Immunofluorescent analysis of paraformaldehyde-fixed rat placenta using SAMHD1 (GB111331) at dilution of 1: 1100 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室