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产品详情
操作说明
注意事项
Product Information
|
Description |
ZAP70 rabbit polyclonal |
|
Protein full name |
Tyrosine-protein kinase ZAP-70 |
|
Synonyms |
70 kDa zeta-chain associated protein, Srk, Syk-related tyrosine kinase, Zap70, Zap-70 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse ZAP70 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse, Rat |
1: 650-1: 1300 |
spleen |
|
IF |
Mouse, Rat |
1: 1000-1: 2000 |
spleen, lymph, thymus |
Background
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Images
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Immunohistochemistry analysis of paraffin-embedded rat spleen using ZAP70 (GB111109) at dilution of 1: 1300 |
|
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Immunofluorescent analysis of paraffin-embedded rat spleen using ZAP70 (GB111109) at dilution of 1: 2000 |
|
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Immunofluorescent analysis of paraffin-embedded rat lymph using ZAP70 (GB111109) at dilution of 1: 1300 |
|
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Immunofluorescent analysis of paraffin-embedded rat thymus using ZAP70 (GB111109) at dilution of 1: 1300 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室