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Anti -TSC-1 Rabbit pAb

价格: 在线咨询
货号:
DRF101666
产品规格:
100 μL
Applications:
Species:
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information



Description

TSC-1 rabbit polyclonal

Protein full name

Hamartin

Synonyms

Tsc1, TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1, TSC-1

Immunogen

Recombinant protein corresponding to Mouse TSC-1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

128 kDa

Observed MW.

128 kDa

Uniprot ID

Q9Y258




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

PC3, Jurkat, 293T




Background


Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein encoded by the TSC1 gene. TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. Tsc1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including Tsc2, therefore preventing their ubiquitination and degradation in the proteasome. TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb, an essential activator of mTORC1. The TSC complex has been implicated as a tumor suppressor.




Images



image.png

Western blot analysis of TSC-1

(GB11882) at dilution of 1: 1000

Lane 1: PC3 cell lysate

Lane 2: Jurkat cell lysate

Lane 3: 293T cell lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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