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产品详情
操作说明
注意事项
Product Information
|
Description |
TSC-1 rabbit polyclonal |
|
Protein full name |
Hamartin |
|
Synonyms |
Tsc1, TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1, TSC-1 |
|
Immunogen |
Recombinant protein corresponding to Mouse TSC-1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
128 kDa |
|
Observed MW. |
128 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human |
1: 500-1: 1000 |
PC3, Jurkat, 293T |
Background
Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein encoded by the TSC1 gene. TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. Tsc1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including Tsc2, therefore preventing their ubiquitination and degradation in the proteasome. TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb, an essential activator of mTORC1. The TSC complex has been implicated as a tumor suppressor.
Images
|
Western blot analysis of TSC-1 (GB11882) at dilution of 1: 1000 Lane 1: PC3 cell lysate Lane 2: Jurkat cell lysate Lane 3: 293T cell lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室