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产品详情
操作说明
注意事项
Product Information
|
Description |
IL-6 rabbit polyclonal |
|
Protein full name |
Interleukin-6 |
|
Synonyms |
IL6, BSF2, HGF, HSF, IFNB2, IL-6, BSF-2, CDF, IFN-beta-2, interleukin 6 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse IL-6 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse,Rat |
1: 500-1: 1600 |
inflammatory lung, kidney |
| IF |
Mouse,Rat |
1: 200-1: 500 |
inflammatory lung, kidney |
Background
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Images
|
|
Immunohistochemistry analysis of paraffin-embedded rat kidney using IL-6 (GB11117) at dilution of 1: 800 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse inflammatory lung using IL-6 (GB11117) at dilution of 1: 800 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
Publications:
|
|
Title |
Journal |
Pubmed ID |
Application |
|
1 |
M10, a Myricetin-3-O-b-D-Lactose Sodium Salt, Prevents Ulcerative Colitis Through Inhibiting Necroptosis in Mice. |
Frontiers in Pharmacology |
33041798 |
WB |
|
2 |
GPA Peptide-Induced Nur77 Localization at Mitochondria Inhibits Inflammation and Oxidative Stress through Activating Autophagy in the Intestine. |
Oxidative Medicine and Cellular Longevity |
32904539 |
WB |
|
3 |
Astragalus membranaceus Injection Suppresses Production of Interleukin-6 by Activating Autophagy through the AMPK-mTOR Pathway in Lipopolysaccharide-Stimulated Macrophages. |
Oxidative Medicine and Cellular Longevity |
32724488 |
WB |
|
4 |
Silencing CDC25A inhibits the proliferation of liver cancer cells by downregulating IL-6 in vitro and in vivo. |
International Journal of Molecular Medicine |
31922225 |
IHC |
|
5 |
Hic-5 deficiency protects cerulein-induced chronic pancreatitis via down-regulation of the NF-κB (p65)/IL-6 signalling pathway. |
Journal of Cellular and Molecular Medicine |
31797546 |
WB |
|
6 |
Xiaoyao Pills Prevent Lipopolysaccharide-Induced Depression by Inhibiting Inflammation and Protecting Nerves. |
Frontiers in Pharmacology |
31798446 |
IHC |
|
7 |
MicroRNA-451 and Genistein Ameliorate Nonalcoholic Steatohepatitis in Mice. |
International Journal of Molecular Sciences |
31816816 |
WB |
|
8 |
The JAK inhibitor tofacitinib ameliorates immune-mediated liver injury in mice. |
Molecular Medicine Reports |
31638166 |
IHC |
|
9 |
Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases. |
Nature Communications |
31040273 |
IF |
|
10 |
Induction of pathological changes and impaired expression of cytokines in developing female rat spleen after chronic excess fluoride exposure. |
Toxicology and Industrial Health |
30463494 |
IHC |
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