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产品详情
操作说明
注意事项
Product Information
|
Description |
p53 mouse monoclonal |
|
Protein full name |
Cellular tumor antigen p53 |
|
Synonyms |
TP53, BCC7, LFS1, P53, TRP53, tumor protein p53 |
|
Immunogen |
Recombinant protein corresponding to Human p53 |
|
Isotype |
IgG1 |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus, Endoplasmic reticulum, Mitochondrion |
|
Predicted MW. |
44 kDa |
|
Observed MW. |
55 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human |
1: 1000-1: 2000 |
HT29, SW480, A549, 293, 293T, U251, T47D |
|
IHC |
Human |
1: 1500-1: 3000 |
ovarian cancer, esophageal cancer, rectal cancer |
Background
Tumor protein p53, also known as p53, cellular tumor antigen p53 , phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), which encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, sense cence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome.
Images
|
|
Western blot analysis of p53 (GB12626) at dilution of 1: 2000 Lane 1: HT29 cell lysate Lane 2: SW480 cell lysate Lane 3: A549 cell lysate Lane 4: 293 cell lysate Lane 5: 293T cell lysate Lane 6: U251 cell lysate Lane 7: T47D cell lysate |
|
|
Immunohistochemistry analysis of paraffin-embedded human ovarian cancer using p53 (GB12626) at dilution of 1: 3000 |
|
|
Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using p53 (GB12626) at dilution of 1: 3000 |
|
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Immunohistochemistry analysis of paraffin-embedded rectal cancer using p53 (GB12626) at dilution of 1: 3000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室