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产品详情
操作说明
注意事项
Product Information
|
Description |
ROR alpha/RORA mouse monoclonal |
|
Protein full name |
Nuclear receptor ROR-alpha |
|
Synonyms |
Nuclear receptor RZR-alpha, Nuclear receptor subfamily 1 group F member 1, RAR-related orphan receptor A, Retinoid-related orphan receptor-alpha, Rora, Nr1f1, Rzra |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse ROR alpha/RORA |
|
Isotype |
IgG2a |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human, Mouse, Rat |
1: 1000-1: 2000 |
kidney cancer, brain, heart |
Background
RORA is a steroid hormone receptor and has been implicated in the pathology of circadian rhythms, bone growth, angiogenesis, development of cones, cellular metabolism and a mediator in the immune and lipid metabolism pathways . It binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence, which binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1 .
Images
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Immunohistochemistry analysis of paraffin-embedded human kidney cancer using RORA (GB121300) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using RORA (GB121300) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded rat brain using RORA (GB121300) at dilution of 1: 2000 |
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Immunohistochemistry analysis of paraffin-embedded mouse heart using RORA (GB121300) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded rat heart using RORA (GB121300) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室