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产品详情
操作说明
注意事项
Product Information
|
Description |
beta Catenin mouse monoclonal |
|
Protein full name |
Catenin beta-1 |
|
Synonyms |
CTNNB1, CTNNB, MRD19, armadillo, catenin beta 1 |
|
Immunogen |
Recombinant protein corresponding to Mouse β-catenin |
|
Isotype |
IgG |
|
Predicted MW. |
92 kDa |
|
Observed MW. |
92 kDa |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
lung, kidney |
|
IHC |
Human, Mouse, Rat |
1: 100-1: 500 |
stomach, colon |
|
IF |
Human, Mouse, Rat |
1: 100-1: 500 |
stomach, colon |
Background
β-catenin is a dual function protein, involved in regulation and coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin, also known as plakoglobin. Beta-catenin is widely expressed in many tissues. In cardiac muscle, beta-catenin localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocytes.
Images
|
|
Western blot analysis of β-catenin (GB12015) at dilution of 1: 1000. Lane 1: Mouse lung tissue lysate Lane 2: Mouse kidney tissue lysate Lane 3: Rat kidney tissue lysate |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse stomach using β-catenin (GB12015)at dilution of 1: 200
|
|
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Immunohistochemistry analysis of paraffin-embedded rat stomach using β-catenin (GB12015)at dilution of 1: 200 |
|
Immunohistochemistry analysis of paraffin-embedded rat colon using β-catenin (GB12015)at dilution of 1: 200 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室