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产品详情
操作说明
注意事项
Product Information
|
Description |
MDM2 rabbit polyclonal |
|
Protein full name |
E3 ubiquitin-protein ligase Mdm2 |
|
Synonyms |
Double minute 2 protein, Oncoprotein Mdm2, RING-type E3 ubiquitin transferase Mdm2, p53-binding protein Mdm2 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse MDM2 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
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Uniprot ID |
Applications
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Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Mouse, Rat |
1: 1000-1: 3000 |
lung, kidney, thymus |
Background
MDM2 is a target of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Over expression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle,apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse lung using MDM2 (GB111161) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded rat lung using DM2 (GB111161) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney using MDM2 (GB111161) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded rat kidney using MDM2 (GB111161) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded mouse thymus using MDM2 (GB111161) at dilution of 1: 1500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室