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产品详情
操作说明
注意事项
Product Information
|
Description |
AKT1 rabbit polyclonal |
|
Protein full name |
RAC-alpha serine/threonine-protein kinase |
|
Synonyms |
AKT1 kinase, Protein kinase B, PKB, Protein kinase B alpha, PKB alpha, Proto-oncogene c-Akt, RAC-PK-alpha, Akt1, Thymoma viral proto-oncogene, Akt |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Rat AKT1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
56 kDa |
|
Observed MW. |
60 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1500 |
heart, brain |
Background
The AKT1 protein plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4.This protein is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
Images
|
|
Western blot analysis of AKT1 (GB111114) at dilution of 1: 1000
|
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室