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Anti -Neurofibromin Rabbit pAb
价格：
在线咨询
货号：
DRF101236
产品规格：
100 μL
Applications：
WB/IHC/IF
Species：
H/M/R,H/M/R,H/M/R
购买数量：
产品详情
操作说明
注意事项
Product Information
|
Description |
Neurofibromin rabbit polyclonal |
|
Protein full name |
Neurofibromin |
|
Synonyms |
Neurofibromatosis-related protein NF-1, Nf1, Neurofibromin, neurofibromin 1, NFNS, VRNF, WSS |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Neurofibromin |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
320 kDa |
|
Observed MW. |
320 kDa |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
lung |
|
IHC |
Human, Mouse, Rat |
1: 1500-1: 4000 |
brain, lung, kidney, colon, testis, ovary |
|
IF |
Human, Mouse, Rat |
1: 750-1: 1500 |
brain, lung, kidney, colon, testis, ovary |
Background
Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).
Images
|
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Western blot analysis of Neurofibromin (GB111112) at dilution of 1: 1000 |
|
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Immunohistochemistry analysis of paraffin-embedded mouse brain using Neurofibromin (GB111112) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded mouse lung using Neurofibromin (GB111112) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded rat kidney using Neurofibromin (GB111112) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse colon using Neurofibromin (GB111112) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse testis using Neurofibromin (GB111112) at dilution of 1: 3000 |
|
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Immunohistochemistry analysis of paraffin-embedded rat ovary using Neurofibromin (GB111112) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室