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Anti -VCP Rabbit pAb

价格: 在线咨询
货号:
DRF101280
产品规格:
100 μL
Applications:
WB
Species:
H/M
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

VCP rabbit polyclonal

Protein full name

Transitional endoplasmic reticulum ATPase

Synonyms

TER ATPase, 15S Mg(2+)-ATPase p97 subunit, Valosin-containing protein, VCP

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse VCP

Isotype

IgG

Purity

Affinity purification

Predicted MW.

89 kDa

Observed MW.

97 kDa

Uniprot ID

P55072, Q01853




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse

1: 500-1: 1000

brain, lung




Background


Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease. VCP has a calculated molecular weight of 89 kDa and an apparent molecular weight of 90-100 kDa.




Images


Western blot analysis of VCP (GB111155) at dilution of 1: 1000
Lane 1: Hela cell lysate
Lane 2: K562 cell lysate
Lane 3: NIH/3T3 cell lysate
Lane 4: HT29 cell lysate
Lane 5: MDA-MB-231 cell lysate
Lane 6: Mouse brain tissue lysate
Lane 7: Mouse lung tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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