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产品详情
操作说明
注意事项
Product Information
|
Description |
VCP rabbit polyclonal |
|
Protein full name |
Transitional endoplasmic reticulum ATPase |
|
Synonyms |
TER ATPase, 15S Mg(2+)-ATPase p97 subunit, Valosin-containing protein, VCP |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse VCP |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
89 kDa |
|
Observed MW. |
97 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse |
1: 500-1: 1000 |
brain, lung |
Background
Valosin-containing protein (VCP or p97) belongs to the AAA (ATPase associated activities) family and acts as a molecular chaperone to a wide variety of cellular activities. Some of these activities include the alteration of both nuclear and mitotic golgi membranes, ubiquitin-proteasome dependent protein degradation, regulation of the NF-kappa b pathway, and extraction of membrane proteins. VCP has been shown to contain a substrate binding domain (N) and two conserved ATPase domains (D1 and D2). The three dimensional structure of VCP resembles that of a cylinder with the D1 and D2 stacked upon one another in a homo-hexameric ring formation. VCP is involved in the formation of neuronal inclusion bodies in neurodegenerative disease such as Parkinson's Disease. VCP has a calculated molecular weight of 89 kDa and an apparent molecular weight of 90-100 kDa.
Images
|
|
Western blot analysis of VCP (GB111155) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室