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Anti -CDKN2A/p16INK4a Rabbit pAb
价格：
在线咨询
货号：
DRF101268
产品规格：
100 μL
Applications：
IHC/IF
Species：
H,H
购买数量：
产品详情
操作说明
注意事项
Product Information
|
Description |
CDKN2A rabbit polyclonal |
|
Protein full name |
Cyclin-dependent kinase inhibitor 2A |
|
Synonyms |
Cyclin-dependent kinase 4 inhibitor A, CDK4I, p16-INK4a, Cdkn2a, P16ink4a |
|
Immunogen |
Recombinant protein corresponding to Mouse CDKN2A |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
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Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human |
1: 500-1: 2000 |
lung cancer, ovarian cancer, breast cancer, colon |
|
IF |
Human |
1: 500-1: 1000 |
breast, colon |
Background
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Images
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using CDKN2A (GB111143) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human ovarian cancer using CDKN2A (GB111143) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human breast cancer using CDKN2A (GB111143) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human colon using CDKN2A (GB111143) at dilution of 1: 1000 |
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Immunofluorescent analysis of paraffin-embedded human breast using CDKN2A (GB111143) at dilution of 1: 1000 |
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Immunofluorescent analysis of paraffin-embedded human colon using CDKN2A (GB111143) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室