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产品详情
操作说明
注意事项
Product Information
|
Description |
p115-RhoGEF rabbit polyclonal |
|
Protein full name |
Rho guanine nucleotide exchange factor 1 |
|
Synonyms |
Lbc's second cousin, Lymphoid blast crisis-like 2, Arhgef1, Lbcl2, Lsc, p115RhoGEF, GEF1, LBCL2LSC |
|
Immunogen |
Recombinant protein corresponding to Mouse p115-RhoGEF |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human, Mouse, Rat |
1: 1000-1: 4000 |
thyroid, thymus, lymph |
|
IF |
Human, Mouse, Rat |
1: 500-1: 3000 |
thyroid, thymus, lymph |
Background
This protein seems to play a role in the regulation of RhoA GTPase by guanine nucleotide binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Images
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Immunohistochemistry analysis of paraffin-embedded human thyroid using p115-RhoGEF (GB111024) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded mouse thymus using p115-RhoGEF (GB111024) at dilution of 1: 2000 |
|
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Immunohistochemistry analysis of paraffin-embedded rat lymph using p115-RhoGEF (GB111024) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室