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Anti -MAdCAM1 Rabbit pAb
价格：
在线咨询
货号：
DRF101121
产品规格：
100 μL
Applications：
IHC/IF
Species：
H/M/R,H/M/R
购买数量：
产品详情
操作说明
注意事项
Product Information
|
Description |
MAdCAM1 rabbit polyclonal |
|
Protein full name |
Mucosal addressin cell adhesion molecule 1 |
|
Synonyms |
MAdCAM-1, mMAdCAM-1, Madcam1, Addressin mucosal, hMAdCAM 1, MACAM1, Mucosal vascular addressin cell adhesion molecule 1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse MAdCAM1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Cell Membrane |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
IHC |
Human, Mouse, Rat |
1: 1000-1: 3000 |
small intestine, colon, pancreas |
|
IF |
Human, Mouse, Rat |
1: 500-1: 3000 |
small intestine, colon, pancreas |
Background
MAdCAM-1 is an immunoglobulin (Ig) cell adhesion molecule family member. MAdCAM-1 is involved in lymphocyte homing to mucosal sites and is expressed on high endothelial venules (HEV) of both mesenteric lymph nodes and Peyer’s patches. It has also been found to be expressed on sinus-lining cells of the spleen. The integrin, alpha 4 beta 7, has been shown to function as the MAdCAM-1 receptor. The Ig domains of MAdCAM-1 have been found to be critical to alpha 4 beta 7 binding. The mucin domain has been shown to have activity in L-Selectin binding. MAdCAM-1 expression has been demonstrated to be up-regulated by TNF-alpha and IL-1 beta. MAdCAM-1 appears to play a role in inflammatory bowel disease (IBD) as its expression is highly up-regulated in IBD and most likely serves to recruit alpha 4 beta 7-expressing lymphocytes to the region. MAdCAM-1/ alpha 4 beta 7 interaction plays a role in diabetes development in this model.
Images
|
Immunohistochemistry analysis of paraffin-embedded mouse small intestine using MAdCAM1 (GB111006) at dilution of 1: 2000 |
|
Immunohistochemistry analysis of paraffin-embedded rat colon using MAdCAM1 (GB111006) at dilution of 1: 2000 |
|
Immunohistochemistry analysis of paraffin-embedded rat pancreas using MAdCAM1 (GB111006) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室