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Product Information
Description |
Gemin 2 rabbit polyclonal |
Protein full name |
Gem-associated protein 2 |
Synonyms |
Gemin2, GEMIN2, SIP1, SIP1-delta, Survival of motor neuron protein-interacting protein 1, gem nuclear organelle associated protein 2 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Gemin 2 |
Isotype |
IgG |
Purity |
Affinity purification |
Subcellular location |
Nucleus |
Predicted MW. |
30 kDa |
Observed MW. |
30 kDa |
Uniprot ID |
O14893, Q9CQQ4 |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
muscle, testis |
IHC |
Mouse, Rat |
1: 1000-1: 2000 |
lung, testis, bone, spinal cord |
IF |
Mouse, Rat |
1: 500-1: 1000 |
lung, testis, bone, spinal cord |
Background
This gene encodes one of the proteins found in the SMN complex, which consists of several gemini proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
Images
Western blot analysis of Gemin 2 (GB11862) at dilution of 1: 1000 Lane 1: HepG2 cell lysate Lane 2: 293T cell lysate Lane 3: Jurkat cell lysate Lane 4: HeLa cell lysate Lane 5: NIH/3T3 cell lysate Lane 6: Mouse muscle tissue lysate Lane 7: Rat muscle tissue lysate Lane 8: Rat testis tissue lysate
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Immunohistochemistry analysis of paraffin-embedded rat lung using Gemin 2 (GB11862) at dilution of 1: 1000
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Immunohistochemistry analysis of paraffin-embedded mouse testis using Gemin 2 (GB11862) at dilution of 1: 1000
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Immunohistochemistry analysis of paraffin-embedded rat testis using Gemin 2 (GB11862) at dilution of 1: 1000
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Immunohistochemistry analysis of paraffin-embedded mouse bone using Gemin 2 (GB11862) at dilution of 1: 1000
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Immunohistochemistry analysis of paraffin-embedded rat spinal cord using Gemin 2 (GB11862) at dilution of 1: 1000
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Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.
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