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Anti -Neurofibromin Rabbit pAb

价格: 在线咨询
货号:
KT011584
产品规格:
100ul
Applications:
WB/IHC/IF
Species:
H/M/R,H/M/R
购买数量:
在线咨询 400-1016-218
产品详情 操作说明 注意事项

Product Information


Description

Neurofibromin rabbit polyclonal antibody

Protein full name

Neurofibromin

Synonyms

Neurofibromatosis-related protein NF-1, Nf1, Neurofibromin, neurofibromin 1, NFNS, VRNF, WSS

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Neurofibromin

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Predicted MW.

320 kDa

Observed MW.

320 kDa

Uniprot ID

P21359, Q04690, P97526




Applications


Applications

Species

Dilution

Positive Sample

WB

Human, Mouse, Rat

1: 500-1: 1000

lung

IHC/IF

Human, Mouse, Rat

1: 750-1: 4000

brain, breast cancer, colon, lung, ovary, Skeletal muscle, testis




Background


Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. 




Images


Picture 1.png

Western blot analysis of Neurofibrmin-1 (GB111112) at dilution of 1: 500

Picture 2.png

Immunohistochemistry of paraffin embedded mouse brain using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)

Picture 3.png

Immunohistochemistry of paraffin embedded mouse colon using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)

Picture 4.png

Immunohistochemistry of paraffin embedded mouse lung using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)

Picture 5.png

Immunohistochemistry of paraffin embedded rat colon using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
Picture 6.png Immunohistochemistry of paraffin embedded rat lung using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
Picture 7.png Immunohistochemistry of paraffin embedded rat skeletal muscle using Neurofibinin (GB111112) at dilution of 1: 2000 (400x lens)
Picture 8.png Immunofluorescence of paraffin embedded human breast cancer using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens)
Picture 9.png Immunofluorescence of paraffin embedded mouse brain using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens)

Picture 10.png

Immunofluorescence of paraffin embedded mouse ovary using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens)

Picture 11.png

Immunofluorescence of paraffin embedded rat testis using Neurofibinin (GB111112) at dilution of 1: 1500 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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