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产品详情
操作说明
注意事项
Product Information
|
Description |
NRG1 rabbit polyclonal antibody |
|
Protein full name |
Pro-neuregulin-1, membrane-bound isoform |
|
Synonyms |
Pro-NRG1, Neuregulin-1, ARIA, Breast cancer cell differentiation factor p45, Glial growth factor, Heregulin, HRGA, NDF, SMDF, HGL,HRG, Neu differentiation factor, Sensory and motor neuron-derived factor, NRG1, GGF |
|
Immunogen |
Recombinant protein corresponding to Human NRG1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
70 kDa |
|
Observed MW. |
55 kDa (mature); 72 kDa (precursor) |
|
Uniprot ID |
Q02297, P43322 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
lung |
Background
The NRG1 was originally identified as a glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.
Images
|
|
Western blot analysis of NRG1 (GB111258) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室