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Product Information
Description |
NK-1R rabbit polyclonal antibody |
Protein full name |
Substance-P receptor |
Synonyms |
Tacr1, TACR1, NK1R, NKIR, SPR, TAC1R, Tachykinin receptor 1 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse TACR1 |
Isotype |
IgG |
Purity |
Affinity purification |
Predicted MW. |
46 kDa |
Observed MW. |
46 kDa |
Uniprot ID |
P25103, P30548, P14600 |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
WB |
Mouse, Rat |
1: 500-1: 1000 |
brain, heart, spinal cord |
Background
The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. It is probably associated with G proteins that activate a phosphatidylinositol calcium second messenger system. The endogenous ligand for this receptor is Substance P. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. The binding of SP to the NK1 receptor has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation.
Images
Western blot analysis of TACR1 (GB11759) at dilution of 1: 500
|
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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