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Product Information
Description |
NK-1R rabbit polyclonal antibody |
Protein full name |
Substance-P receptor |
Synonyms |
Tacr1, TACR1, NK1R, NKIR, SPR, TAC1R, Tachykinin receptor 1 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse TACR1 |
Isotype |
IgG |
Purity |
Affinity purification |
Predicted MW. |
46 kDa |
Observed MW. |
46 kDa |
Uniprot ID |
P25103, P30548, P14600 |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
WB |
Mouse, Rat |
1: 500-1: 1000 |
brain, heart, spinal cord |
Background
The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. It is probably associated with G proteins that activate a phosphatidylinositol calcium second messenger system. The endogenous ligand for this receptor is Substance P. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. The binding of SP to the NK1 receptor has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation.
Images
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Western blot analysis of TACR1 (GB11759) at dilution of 1: 500
|
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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