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产品详情
操作说明
注意事项
Product Information
|
Description |
Tollip rabbit polyclonal |
|
Protein full name |
Toll-interacting protein |
|
Synonyms |
TOLLIP, IL-1RAcPIP, toll interacting protein |
|
Immunogen |
Recombinant protein corresponding to Mouse Tollip |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
|
|
Predicted MW. |
30 kDa |
|
Observed MW. |
30 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Mouse, Rat |
1 :500-1: 1000 |
brain, spleen, thymus |
|
IHC |
Human, Mouse, Rat |
1: 1000-1: 2000 |
liver cancer, spleen, brain, kidney, lung |
|
IF |
Human, Mouse, Rat |
1: 500-1: 1000 |
liver cancer, spleen, brain, kidney, lung |
Background
The Tollip is the component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates
Images
|
|
Western blot analysis of NCR1 (GB111102) at dilution of 1: 1000 |
|
|
Immunohistochemistry analysis of paraffin-embedded human liver cancer using Tollip (GB111093) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded mouse spleen using Tollip (GB111093) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded rat kidney using Tollip (GB111093) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded rat brain using Tollip (GB111093) at dilution of 1: 2000 |
|
|
Immunohistochemistry analysis of paraffin-embedded rat lung using Tollip (GB111093) at dilution of 1: 2000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
QQ：355185756
地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室