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产品详情
操作说明
注意事项
Product Information
|
Description |
Perforin rabbit polyclonal |
|
Protein full name |
Perforin-1 |
|
Synonyms |
P1, Cytolysin, Lymphocyte pore-forming protein, PFP, PRF1, FLH2, HPLH2, MGC65093, Perforin 1, Perforin 1 precursor, Perforin 1 preforming protein, PGFL, PIGF, PIGF-2, PLGF, SHGC-10760 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Human Perforin |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Predicted MW. |
61 kDa |
|
Observed MW. |
70 kDa |
|
Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Rat |
1: 500-1: 1000 |
thymus, spleen, lung |
Background
Perforin 1 is one of the major cytolytic proteins of cytolytic granules. It is known to be a crucial effector molecule in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. This protein has structural and functional similarities to complement component C9. Like C9, this protein creates transmembrane tubules and is capable of lysing nonspecifically a variety of target cells. Defects in PRF1 are the cause of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood，which is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function. Alternative splicing results in multiple transcript variants encoding the same protein.
Images
|
Western blot analysis of Perforin (GB11943) at dilution of 1: 800 Lane 1: Jurkat cell lysate Lane 2: THP-1 cell lysate Lane 3: SW480 cell lysate Lane 4: Mouse thymus tissue lysate Lane 5: Rat spleen tissue lysate Lane 7: Rat lung tissue lysate Lane 8: Rat thymus tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
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地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室