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产品详情
操作说明
注意事项
Product Information
| Description |
Fas Ligand rabbit polyclonal |
| Protein full name |
Tumor necrosis factor ligand superfamily member 6 |
|
Synonyms |
FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, Fas ligand |
| Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse FASL |
| Isotype | IgG |
| Purity | Affinity purification |
| Predicted MW. |
31KDa |
| Observed MW. |
31KDa |
| Uniprot ID |
Applications
|
Applications |
Species |
Dilution |
Positive Tissue |
|
WB |
Human, Mouse, Rat |
1:500-1:1000 |
LNCap,breast cancer,liver,spleen,brain |
Background
Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells . Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development . Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways . Can induce apoptosis but does not appear to be essential for this process.
Images
|
|
Western blot analysis of FASL(GB11090) at dilution of 1:1000. Lane 1:LNCaP cell tissue lysate Lane 2:Human breast cancer tissue lysate Lane 3:Mouse liver tissue lysate Lane 4:Mouse spleen tissue lysate Lane 5:Mouse brain tissue lysate Lane 6:Rat liver tissue lysate Lane 7:Rat spleen tissue lysate |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥万物生物科技有限公司
客服热线：400-1016-218
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地址：安徽省合肥市高新区黄山路602号合肥国家大学科技园A401室