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中文名称:DTX2抗原(重组蛋白)
英文名称: DTX2 Antigen (Recombinant Protein)
储 存: 冷冻(-20℃)
相关类别: 抗原
概述
Fusion protein corresponding to a region derived from 323-622 amino acids of human DTX2 |
技术规格
Full name: |
deltex E3 ubiquitin ligase 2 |
Synonyms: |
RNF58 |
Swissprot: |
Q86UW9 |
Gene Accession: |
BC018555 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. |
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